Publications by authors named "A J C Kuehne"
The efficiency of kinase inhibiting cancer therapeutics is often limited by their poor solubility in water. PEGylation is one possible strategy to improve the solubility of the drug, however, means to cleave these after reaching the target is important to make use of the therapeutic effects of the native drug. Moreover, the length of the PEG chains will have an effect on the solubility and binding.
View Article and Find Full Text PDFCrimean-Congo hemorrhagic fever virus (CCHFV) is a tickborne virus that can cause severe disease in humans with case fatality rates of 10%-40%. Although structures of CCHFV glycoproteins GP38 and Gc have provided insights into viral entry and defined epitopes of neutralizing and protective antibodies, the structure of glycoprotein Gn and its interactions with GP38 and Gc have remained elusive. Here, we use structure-guided protein engineering to produce a stabilized GP38-Gn-Gc heterotrimeric glycoprotein complex (GP38-Gn-Gc).
View Article and Find Full Text PDFArticle Synopsis
- * An online survey conducted by the German Society for Public Health Services (DGÖG) gathered input from nearly 500 participants, primarily from local health departments, to prioritize 17 proposed guideline topics across six task areas.
- * All 17 topics were deemed high priority, with a strong emphasis on infection hygiene monitoring, medical expert assessment, and psychosocial emergency care, while additional topics such as health promotion and crisis management were also highlighted for future guideline development.
Background: Utilizing regional health data goes hand in hand with challenges: can they be used for health planning, are they applicable to the relevant topics? The study explores current data utilization and needs of stakeholders working in regional health services planning.
Methods: We conducted 16 semi-structured expert-interviews with stakeholders of regional health planning in Brandenburg, a federal state in the north-east of Germany, by telephone or online-meeting tools between 05/2022 and 03/2023. The data were analysed according to qualitative content analysis.