Publications by authors named "A J Buendia"
Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types.
View Article and Find Full Text PDFIntegrons are key elements in the rise and spread of multidrug resistance in Gram-negative bacteria. These genetic platforms capture cassettes containing promoterless genes and stockpile them in arrays of variable length. In the current integron model, expression of cassettes is granted by the P promoter in the platform and is assumed to decrease as a function of its distance.
View Article and Find Full Text PDFIn ovine populations, the enzootic nature of () is attributed to its capacity to establish persistent intracellular infections, which necessitate a cellular immune response mediated by interferon-gamma (IFN-) for effective resolution. In both natural hosts and murine models, interleukin-10 (IL-10) has been demonstrated to modulate the cellular immune response crucial for the eradication of . During gestation, it has also been shown to play a role in preventing inflammatory damage to gestational tissues and foetal loss through the downregulation of pro-inflammatory cytokines.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how concave and cylindrical abutments affect peri-implant soft tissue by measuring dimensions, collagen fiber orientation, and inflammatory responses in a randomized clinical trial involving 37 patients.
- - Results showed that concave abutments led to significantly greater tissue height and barrier epithelium extension compared to cylindrical abutments, alongside more favorable collagen fiber alignment.
- - Immunohistochemical analysis indicated lower inflammation with concave abutments, although both types showed similar vascular intensity; tissue remnants were also more prevalent on concave abutments.
Article Synopsis
- Some people are trying to figure out if waiting to cut the umbilical cord affects how much useful blood can be collected for banking.
- The study looked at data from hospitals in Spain where babies were born normally and compared how much blood was collected based on waiting 30 seconds, 60 seconds, or more than 120 seconds before clamping the cord.
- They found that while waiting longer means you get less blood overall, the important parts of the blood still remained good, so all the waiting times still work for storing the blood for later use.