Publications by authors named "A J Breen"
Electrospun nanofibrous mats, consisting of chitosan (CS) and polyvinylpyrrolidone (PVP), were constructed with the addition of graphene oxide (GO) for enhancement of delivery of the 5-Fluorouracil (5-Fu) chemotherapy drug. Upon studying the range of GO concentrations in CS/PVP, the concentration of 0.2% / GO was chosen for inclusion in the drug delivery model.
View Article and Find Full Text PDFEffect of asymptomatic intervertebral flexion patterns on lumbar disc pressure: A finite element analysis study.
Int J Numer Method Biomed Eng
November 2024
Article Synopsis
- Movement patterns can influence the load on the lumbar spine, yet specific research on their connection to intervertebral disc pressure (IDP) is limited.
- A finite element model of a 49-year-old female's lumbar spine was used to analyze the lumbar movements of 127 asymptomatic participants during flexion, focusing on two simulation stages: lumbar pattern exchange (LPE) and vertebral pattern exchange (VPE).
- Findings indicate that while temporal movement patterns didn't significantly affect peak IDP, certain patterns did influence cumulative IDP, highlighting the potential for modifying lumbar IDP through changes in movement timing, which could help in developing prevention and treatment strategies for lumbar issues.
Background: The calculation of remaining growth in children and the timing of epiphysiodesis in those with leg-length discrepancy (LLD) is most often done with 4 methods: the Green-Anderson, White-Menelaus, Moseley straight-line graph, and multiplier methods. The aims of this study were to identify the most accurate method with use of bone age or chronological age and to evaluate the influence of including inhibition in the calculations.
Methods: One hundred and ninety-one children (10 to 17 years of age) with LLD who underwent surgical closure of the growth plate and were followed until skeletal maturity were identified from a local health register.
Medium- and high-entropy alloys are an emerging class of materials that can exhibit outstanding combinations of strength and ductility for engineering applications. Computational simulations have suggested the presence of short-range order (SRO) in these alloys, and recent experimental evidence is also beginning to emerge. Unfortunately, the difficulty in quantifying the SRO under different heat treatment conditions has generated much debate on the atomic preferencing and implications of SRO on mechanical properties.
View Article and Find Full Text PDFPurpose: In vivo studies of continuous lumbar sagittal plane motion have found passive intervertebral motion to be more uneven in patients with chronic nonspecific low back pain (CNSLBP) than healthy controls, but the mechanisms are unclear. This study aimed to compare patients with CNSLBP with a matched group of pain-free controls for intervertebral restraint during passive recumbent bending.
Methods: Seventeen patients with CNSLBP and minimal disc degeneration who had quantitative fluoroscopy investigations were matched to 17 healthy controls from a database acquired using the same imaging protocol.