Publications by authors named "A J Brearley"
Article Synopsis
- Gadolinium-based contrast agents are commonly used in medical imaging but have been linked to health issues like nephrogenic systemic fibrosis and encephalopathy after exposure.
- These agents are designed to bind gadolinium tightly to minimize toxicity, but there's concern that uncoupled gadolinium could be harmful.
- Recent research from the Kidney Institute of New Mexico discovered gadolinium-rich nanoparticles in human kidney cells, suggesting these particles may contribute to long-term toxicity from contrast agents.
Article Synopsis
- Self-management of medications is affected by various factors and the need for new strategies is highlighted due to continuous issues with improper medication use, resulting in drug-related health complications.
- Innovative initiatives have been developed to help patients confidently manage their medications, including a comprehensive 4-step pharmacotherapy assessment process.
- Initial evaluations of a toolkit designed to assist in medication self-management showed favorable responses from participants, with a strong reliability score indicating the checklist's effectiveness in enhancing self-efficacy in medication management.
Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.
Environ Health Perspect
May 2024
Background: Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes within the intestinal epithelial cells and impacts on lineage differentiation are largely unknown.
Objectives: Herein, we sought to determine the molecular and cellular changes that occur in the colon in response to uranium bearing dust (UBD) exposure.
Prcis: This meta-analysis examines the comparative efficacy of phacoemulsification with and without Kahook Dual Blade Goniotomy in individuals with glaucoma and cataract, aiming to elucidate optimal surgical approaches for coexisting conditions.
Purpose: The purpose of this current study is to compare the effect of combining Kahook Dual Blade (KDB) goniotomy with phacoemulsification versus phacoemulsification alone on intraocular pressure (IOP) and medication reduction in patients with glaucoma and cataract.
Methods: We conducted a systematic review and meta-analysis utilizing computer databases, including Embase (OVID), MEDLINE (OVID and PubMed), CINHAL (EBSCO), and the Cochrane Library (Wiley).