Publications by authors named "A J Bergeron"
Calcific aortic valve disease (CAVD) shows in the deposition of calcium phosphates in the collagen-rich layer of the valve leaflets. This stiffens the leaflets and eventually leads to heart failure. Recent research suggests that CAVD follows sex-specific pathways: at the same severity of the disease, women tend to have fewer and less crystalline calcifications, and the phases of their calcifications are decidedly different than those of men; namely, dicalcium phosphate dihydrate (DCPD) - one of the mineral phases in CAVD - occurs almost exclusively in females.
View Article and Find Full Text PDF: Pancreatic ductal adenocarcinoma (PDAC) is a cancer with very poor prognosis despite early surgical management. To date, only clinical variables are used to predict outcome for decision-making about adjuvant therapy. We sought to generate a deep learning approach based on hematoxylin and eosin (H&E) or hematoxylin, eosin and saffron (HES) whole slides to predict patients' outcome, compare these new entities with known molecular subtypes and question their biological significance; : We used as a training set a retrospective private cohort of 206 patients treated by surgery for PDAC cancer and a validation cohort of 166 non-metastatic patients from The Cancer Genome Atlas (TCGA) PDAC project.
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- Febrile neutropenia (FN) is a serious condition that can lead to significant health issues, and imaging plays a key role in diagnosing its causes through CT scans of the paranasal sinuses, chest, and abdomen/pelvis.
- A study of 306 FN patients found that over 61% had positive CT findings, with half diagnosed with an infection, particularly when they showed specific clinical signs, leading to changes in treatment.
- The findings suggest that systematic chest CT scans are advised for FN patients, and using abdomen/pelvis CTs may also be beneficial, but more research is needed to understand their impact on patient outcomes.
Background: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease that may progress towards pulmonary fibrosis. Data about fibrosis prevalence and risk factors are lacking.
Methods: In this retrospective multicentre nationwide cohort, we included patients newly diagnosed with aPAP between 2008 and 2018 in France and Belgium.