Publications by authors named "A J Berends"
Article Synopsis
- The aim was to determine whether continuous or multiple daily doses of PTH would be more effective in reducing urinary calcium excretion and lowering the nephrolithiasis risk, using a pharmacokinetic-pharmacodynamic (PKPD) model.
- The results indicated that continuous PTH infusion significantly improved phosphate clearance, although its effect on calcium clearance was less pronounced, suggesting that further research on continuous administration is warranted.
Photobiomodulation (PBM) therapy is the application of near-infrared (NIR) exposure to injuries or lesions to (among others) improve wound healing, reduce inflammation, and decreases acute and chronic pain. However, the understanding of the molecular mechanism of PBM, more specifically the effects of NIR on skin cells is still lacking behind. Lipids are essential components of cellular membranes that are integral to skin structure and function.
View Article and Find Full Text PDFDegenerative joint disease osteoarthritis (OA) is characterized by the degeneration of cartilage, synovial inflammation and low-grade systemic inflammation in association with microbial dysbiosis and intestinal barrier defects. Butyrate is known for its anti-inflammatory and barrier protective effects and might benefit OA patients. In a double-blind placebo-controlled randomized trial, the effects of four to five weeks of oral treatment with sustained-release (SR) butyrate tablets (600 mg/day) on systemic inflammation and immune function were studied in hand OA patients.
View Article and Find Full Text PDFUpdate on clinical characteristics in the evaluation of phaeochromocytoma and paraganglioma.
Best Pract Res Clin Endocrinol Metab
December 2024
Article Synopsis
- Pheochromocytomas and sympathetic paragangliomas (PPGL) are rare neuroendocrine tumors that can be difficult to diagnose due to their varied symptoms, which often resemble other conditions.
- These tumors have shifted from being diagnosed mostly after death to being discovered incidentally or through screening, thanks to improved clinical scoring systems that help identify at-risk patients.
- Management of PPGL has advanced with new treatment options, but it remains a significant concern in pregnant patients due to high mortality risks, emphasizing the need for increased awareness and prompt diagnosis.
Article Synopsis
- The study investigates the factors leading to missed presurgical diagnoses of paragangliomas of the urinary bladder (UBPGLs), rare neuroendocrine tumors that pose diagnostic challenges.
- Out of 124 patients analyzed from multiple regions, only about 47.6% were diagnosed before surgery, with those diagnosed earlier being younger and having larger tumors.
- Key symptoms like micturition spells, hypertension, and sweating were found to significantly increase the likelihood of early biochemical testing, suggesting they could help establish timely diagnoses.