Publications by authors named "A J Bast"
Article Synopsis
- Mold growth on body donations is a significant yet overlooked issue in anatomical education, posing health risks and raising ethical concerns for students and lecturers.* -
- Air samples from dissection courses showed no fungi, suggesting that outdoor air contamination is not influenced by indoor presence, while ventilation filters were effective in reducing fungal germs.* -
- The study found that embalming with ethanol-formalin effectively prevents bacterial and fungal contamination in body donations, indicating a successful long-term preservation method.*
Background: Vitamin K is essential for numerous physiological processes, including coagulation, bone metabolism, tissue calcification, and antioxidant activity. Deficiency, prevalent in critically ill ICU patients, impacts coagulation and increases the risk of bleeding and other complications. This review aims to elucidate the metabolism of vitamin K in the context of critical illness and identify a potential therapeutic approach.
View Article and Find Full Text PDFSarcoidosis is a systemic inflammatory disorder characterized by granuloma formation in various organs. It has been associated with nephrolithiasis. The vitamin K epoxide reductase complex subunit 1 () gene, which plays a crucial role in vitamin K metabolism, has been implicated in the activation of proteins associated with calcification, including in the forming of nephrolithiasis.
View Article and Find Full Text PDFNeurons in the cerebral cortex receive thousands of synaptic inputs per second from thousands of presynaptic neurons. How the dendritic location of inputs, their timing, strength, and presynaptic origin, in conjunction with complex dendritic physiology, impact the transformation of synaptic input into action potential (AP) output remains generally unknown for in vivo conditions. Here, we introduce a computational approach to reveal which properties of the input causally underlie AP output, and how this neuronal input-output computation is influenced by the morphology and biophysical properties of the dendrites.
View Article and Find Full Text PDFArticle Synopsis
- Infantile inflammatory bowel disease (IBD) primarily affects children under two years, often involving genetic factors and tends to be more severe and resistant to standard treatments compared to older children with IBD.
- A 16-month-old boy with consanguineous parents experienced severe IBD symptoms, including perianal fistulas and growth issues, leading to surgery and a diagnosis of Crohn's disease.
- Genetic testing identified mutations in receptor-interacting protein kinase 1, and despite starting a treatment regimen involving adalimumab, he developed further complications requiring additional surgical intervention.