Publications by authors named "A J A Lambeck"
Background: Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non-human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney transplantation. Therefore, we hypothesized that donor-recipient non-HLA genetic mismatch is associated with increased ACR incidence post-liver transplantation.
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- Infliximab is used to treat inflammatory bowel disease (IBD) and its trough concentrations (C-troughs) are important for optimizing treatment efficacy, traditionally measured using ELISA tests.
- A study compared the new Quantum Blue® lateral flow test with traditional ELISA for measuring C-troughs in 100 young IBD patients and found that both methods had good agreement, particularly in low-range measurements.
- The results indicated that lateral flow tests are a reliable, quicker alternative to ELISA, allowing for timely dose adjustments in patients experiencing active disease.
The HLA-B*51:197 allele is generated from the interlocus recombination of both HLA-B*51:01:01:01 and HLA-C*01:02:01:01 alleles.
View Article and Find Full Text PDFIn kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs.
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