Publications by authors named "A Iu Ulitin"
Article Synopsis
- Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
- Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
- Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.
Article Synopsis
- Recent research highlights a growing interest in social innovations in health, but there's a lack of training tailored to boost research capabilities in low- and middle-income countries (LMICs).
- A multi-phase investigation involving surveys and group discussions identified training needs, leading to a series of co-created workshops designed for LMIC researchers in the Social Innovation in Health Initiative (SIHI) network.
- The final evaluation showed that most participants rated the workshops highly, with a strong emphasis on the need for training in writing research grants and manuscripts, suggesting that locally developed training may be more effective than externally designed programs.
Intraoperative photodynamic therapy in complex treatment of malignant gliomas.
Zh Vopr Neirokhir Im N N Burdenko
February 2023
Unlabelled: Treatment of malignant gliomas is an extremely difficult objective associated with difficult choice of correct strategy. Photodynamic therapy is still not the treatment standard in these patients although this approach significantly improves treatment outcomes in surgery of gliomas.
Objective: To demonstrate the possibilities of chlorin e6-mediated photodynamic therapy for malignant glial tumors.
Immune checkpoint inhibitors (ICI) are a standard in cancer therapy, but few patients respond to the treatment. The aim of the present study was the determination of immunological markers for monitoring response to ICI. The present study included 74 patients receiving ICI in subsequent [group 1; non-small cell lung cancer (NSCLC)] and first-line setting (group 2; melanoma) and 30 patients with NSCLC receiving first-line chemotherapy.
View Article and Find Full Text PDFObjectives: Development of a Community Engagement Package composed of (1) database of community engagement (CE) experiences from different contexts, (2) CE learning package of lessons and tools presented as online modules, and (3) CE workshop package for identifying CE experiences to enrich the CE database and ensure regular update of learning resources. The package aims to guide practitioners to promote local action and enhance skills for CE.
Setting And Participants: The packages were co-created with diverse teams from WHO, Social Innovation in Health Initiative, UNICEF, community practitioners, and other partners providing synergistic contributions and bridging existing silos.