[Characteristics of cellular immunosuppression models of allotransplantation reactions].

Two developed experimental models based on induction of suppression by alloantigens in mice and on testing of its effect on the level of proliferative immune reaction during systemic or local adoptive transfer of spleen suppressor cells to syngeneic mice were used. Formation of immunosuppressive mechanisms has been shown to depend on alloantigen (H-2, Mls) properties. Dynamics of suppression development, a degree of its specificity, role of T cells and macrophages in suppression and sensitivity to cyclophosphamide were studied.

[Effect of the splenic cells of tumor-bearing mice on the allograft immune response].

An earlier experimental model employing quantitative analysis of allotransplantation immune response in vivo and registration of the functional activity of immunoregulatory cells was used. It was established that syngeneic transfer of spleen cells from mice bearing 20-methylcholanthrene-induced tumors to normal intact mice modifies immune response to allogeneic cells. The effect of splenocytes was found to depend on the rate of tumor growth.