Publications by authors named "A Iu Perov"
A continuously-tunable terahertz (THz) bandpass filter based on the resonant electromagnetic-wave transmission through a metal-hole array featuring a gradually changing period was developed and fabricated on a silicon substrate using optical lithography. A gradient geometry of the metal-hole array yields a wide tunability of the filter transmission, when operating with a focussed THz beam. The filter was studied numerically, using the finite element method, and experimentally, using the THz pulsed spectroscopy.
View Article and Find Full Text PDFAttitude determination systems based on Global Navigation Satellite Systems (GNSS) work on principle of phase interferometer, using multiple receiving antennas. They rely on a good quality of carrier phase tracking, that is not the case in real dynamic environment with low signal-to-noise ratio (SNR), for example, in a ground vehicle moving through an urban area or forest. There is still a problem in providing a GNSS attitude in such common conditions.
View Article and Find Full Text PDFWe describe a Lab-on-a-Film disposable that detects multidrug-resistant tuberculosis (MDR-TB) from sputum extracts. The Lab-on-a-Film disposable consists of 203 gel elements that include DNA sequences (probes) for 37 mutations, deletions, or insertion elements across 5 genes (including an internal control). These gel elements are printed on a flexible film, which costs approximately 500 times less than microarray glass.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create an easy-to-use gel microarray test for detecting influenza viruses, assessing their subtypes and resistance to neuraminidase inhibitors.
- A single user could perform up to 24 tests in 8 hours with high sensitivity, especially for the A/H1 pdm09 HA gene that detected fewer than 100 gene copies.
- The test results for influenza typing and subtyping matched with traditional RT-PCR results over 97% of the time, showcasing its potential as a reliable diagnostic tool.
Article Synopsis
- Simplifying the microarray workflow is essential for developing diagnostics for MDR-TB that can be used in low-resource settings; this involves integrating multiple processes into a single microfluidic chamber.* -
- The described protocol utilizes a 9-plex asymmetric master mix and can accurately genotype MDR-TB in just 6 hours using a minimum of 1,000 cell equivalents of genomic DNA.* -
- This streamlined approach reduces the complexity and time involved in microarray diagnostics, making it more practical for everyday use in clinical settings.*