[Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].

Three genes mutations in which cause familial forms of Alzheimer's disease are known to date:PSEN1, PSEN2 and APP; and APOE gene polymorphism is a strong risk factor for Alzheimer's disease. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in clusterin (CLU) gene (or apolipoprotein J, APOJ) in populations of three Russian regions and i nAlzheimhner's diseasepatients. Genome-wideassociation studies in samples from several European populations have recently revealed highly significant association o fCLU gene with AD (p = 8.

[Formation of quasilinear domain structures in lipid membranes].

The process of domain lipid structure formation in phoshatidylcholine layer is studied in the context of phase separation theory for two-component mixtures. Computer simulation has shown that as the result of distinctions of structure of hydrocarbon chain-in all-trans and gauche states phase separation of different lipid conformers occurs and quasilinear domain structure is formed in the region of pretransition. The repeat distance of obtained domain structure is reasonable agreement with the experimental data of the ripple mode in phase P beta, of phoshatidylcholine bilayer.