[Increasing the cumulative live birth rate: Low-grade blastocysts, potential overlook].

It is now widely recognized that, following prolonged culture, the transfer of a high-quality morphologically graded blastocyst is the preferred strategy in embryo transfer. Low-grade blastocysts are often considered to have a low implantation potential, and their use remains highly limited. We conducted a general review of the literature, including publications from August 2017 to October 2023, to assess the current state of knowledge regarding these embryos, which are generally excluded in routine practice.

[On the anniversary of Academician, Arkhangelsk State Medical Institute Graduate, Anatoly Alexeevich Kulakov].

Anatoly Alekseevich Kulakov was born on October 18, 1949 on the shore of the Pacific Ocean in the village of Burevestnik, Kuril District, Sakhalin Oblast. His father was a serviceman; the family moved frequently. In 1966, Anatoly Kulakov graduated from secondary school No.

A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in .

Apical extracellular matrices (aECMs) act as crucial barriers, and communicate with the epidermis to trigger protective responses following injury or infection. In , the skin aECM, the cuticle, is produced by the epidermis and is decorated with periodic circumferential furrows. We previously showed that mutants lacking cuticle furrows exhibit persistent immune activation (PIA).

InterPro: the protein sequence classification resource in 2025.

InterPro (https://www.ebi.ac.

ECOD: integrating classifications of protein domains from experimental and predicted structures.

The evolutionary classification of protein domains (ECOD) classifies protein domains using a combination of sequence and structural data (http://prodata.swmed.edu/ecod).