Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia.

Pharmaceuticals and environmental contaminants contribute to hypercholesterolemia. Several chemicals known to cause hypercholesterolemia, activate pregnane X receptor (PXR). PXR is a nuclear receptor, classically identified as a sensor of chemical environment and regulator of detoxification processes.

Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy.

Introduction: Selective serotonin reuptake inhibitors (SSRIs) are commonly used medication for the treatment of depression during pregnancy. Their use may affect various biological molecules such as enzymes which regulate placental hormonal production and xenobiotic metabolism. Our aim was to investigate the effect of maternal SSRI use on activities of three placental enzymes.

Anxiety symptoms in adolescents at risk for psychosis: a comparison among help seekers.

Background: Several studies have reported on how anxiety disorders and anxiety symptoms are already present before the onset of psychosis. However, anxiety disorders are typically studied in these studies at diagnosis-level. The aim of present study was to investigate the profile of anxiety symptoms in subjects at risk of developing psychosis and to compare the anxiety profile with those who are not at risk.

Lower functioning predicts identification of psychosis risk screening status in help-seeking adolescents.

Aim: There is some previous evidence suggesting that the risk state for psychosis is associated with decreased functioning ability, health-related quality of life (QoL), anxiety and depression. The aim of this study is to identify which factors predict psychosis risk screening status.

Methods: The data were collected in Helsinki University Central Hospital, Finland, by an early intervention team.

Changes in health-related quality of life and functioning ability in help-seeking adolescents and adolescents at heightened risk of developing psychosis during family- and community-oriented intervention model.

Abstract Objective. Early intervention has been shown to benefit people at-risk for psychosis, but knowledge about how early intervention benefits all help-seeking adolescents is lacking. The aim of the present study was to study change in health-related quality of life (QoL) and functioning ability in help-seeking adolescents who participate in a community- and family-oriented early intervention program.