Publications by authors named "A Isikdogan"

To evaluate radiological and clinical features in metastatic anaplastic lymphoma kinase+ non-small cell lung cancer patients and crizotinib efficacy in different lines. This national, non-interventional, multicenter, retrospective archive screening study evaluated demographic, clinical, and radiological imaging features, and treatment approaches in patients treated between 2013-2017. Totally 367 patients (54.

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Objectives: In this study, we aimed to investigate the causes of liver test abnormalities in newly diagnosed patients naive to anti-tumoral therapy.

Method: This study included a total of 490 patients with ALT levels > 5X ULN on liver function tests at the initial presentation to our clinic. Data from 247 (50.

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Article Synopsis
  • ALK mutations occur in about 3-5% of non-small cell lung cancer (NSCLC) patients, with pleural involvement or effusion (Ple-I/E) commonly seen in those with ALK positivity.
  • This multicenter study analyzed 362 ALK-positive NSCLC patients, finding that 15.7% had Ple-I/E at diagnosis, with no significant link to gender or other metastases characteristics.
  • Patients with Ple-I/E exhibited significantly better median progression-free survival (18.7 months) and overall survival (44.6 months) compared to those without Ple-I/E, pointing to a potentially more favorable prognosis.
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Aim: Metastatic stage gastric cancer is a disease with a poor prognosis and the likelihood of achieving a cure in these patients is low. Treatment response to subsequent-line treatments is poor. We aimed to investigate the effectiveness of the folinic acid, fluorouracil and irinotecan (FOLFIRI) and paclitaxel+carboplatin regimens, which are used in subsequent lines of therapy in advanced-stage gastric cancer.

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Importance: Cancer was a common noncommunicable disease in Syria before the present conflict and is now a major disease burden among 3.6 million Syrian refugees in Turkey. Data to inform health care practice are needed.

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