Publications by authors named "A Isberg"
Mobile health technologies in an interventional hybrid study on actinic keratosis: Results from an early phase randomized controlled trial investigating the safety and efficacy of a cytosolic phospholipase A2 inhibitor gel in photodamaged skin.
Exp Dermatol
April 2024
Hybrid trials are a new trend in dermatological research that leverage mobile health technologies to decentralize a subset of clinical trial elements and thereby reduce the number of in-clinic visits. In a Phase I/IIa randomized controlled hybrid trial, the safety and efficacy of an anti-proliferative and anti-inflammatory drug inhibiting cytosolic phospholipase A2 (AVX001) was tested using 1%, 3% or vehicle gel in 60 patients with actinic keratosis (AK) and assessed in-clinic as well as remotely. Over the course of 12 weeks, patients were assessed in-clinic at baseline, end of treatment (EOT) and end of study (EOS), as well as 9 times remotely on a weekly to biweekly basis.
View Article and Find Full Text PDFObjectives: Sidekick Health launched a 16-week digital support programme for people with rheumatoid arthritis in 2021. The objective of this retrospective analysis was to understand whether quality of life (QoL; sleep quality, energy and stress levels) improved for users engaged with the programme in a real-world setting.
Methods: This analysis included 635 users who engaged with the programme after the first week, out of 1541 who enrolled.
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition linked with obesity, type 2 diabetes, and metabolic syndrome, which increases cardiovascular disease risk, but lifestyle changes can enhance health outcomes.
- This study evaluated a 12-week digital health program aimed at improving engagement, retention, and user satisfaction while monitoring health changes related to weight and metabolic factors among individuals with NAFLD, obesity, or diabetes.
- Among the 38 participants, 89% completed the program, reporting high satisfaction (median score of 6.3/7), with an average weight loss of 3.5 kg and notable improvements in overall metabolic health indicators.
Background: Wide-ranging patient recruitment not restricted to the location of the investigator will provide a better representation of the patient population in clinical studies.
Objective: Our goal was to assess the feasibility of a broad web-based recruitment strategy in an 8-week observational study of 500 study participants with psoriasis and healthy controls from locations remote from the investigator and to assess the cost associated with each participant.
Methods: A decentralized team in Denmark recruited patients with psoriasis and healthy controls using Google and Facebook advertisements and posts to Facebook groups.