Publications by authors named "A Isaza"
Triiodothyronine levels in athyreotic pediatric patients during levothyroxine therapy.
Front Endocrinol (Lausanne)
August 2024
Objective: Levothyroxine (LT) monotherapy is the current recommended approach for treating pediatric patients post-total thyroidectomy (TT) based on the assumption that peripheral conversion of thyroxine (T) to triiodothyronine (T) normalizes thyroid hormone levels. In adults, approximately 15% of post-TT patients on LT4 monotherapy have altered T:T ratios with ongoing debate in regard to the clinical impact with respect to health-related quality of life (hrQOL). The ability to normalize T and T levels on LT monotherapy for pediatric patients' post-TT is important but not previously described.
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- MCT8 deficiency is a rare, X-linked disorder caused by mutations affecting thyroid hormone transport, leading to severe developmental delays and motor disabilities due to insufficient thyroid hormone in the brain.
- Diagnosis and treatment of MCT8 deficiency face major challenges, including a lack of awareness among healthcare professionals, resulting in misdiagnoses and delays, as well as complex symptoms that may not surface until months after birth.
- Multidisciplinary care is essential for optimal patient support, and while there are no specific treatments available yet, early diagnosis can help improve access to supportive care and developing interventions to enhance the quality of life for patients and their families.
Receptor tyrosine kinase (RTK) fusions of , and are enriched among pediatric thyroid cancer patients with metastatic and persistent disease, and their oncoproteins represent attractive drug targets. We performed RNA-sequencing in a papillary thyroid cancer (PTC) lacking other frequent driver alterations. We report a novel RTK fusion, -insulin-like growth factor 1 receptor gene (), in a 17-year-old female patient with angioinvasive follicular variant PTC.
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- The study examines the American Thyroid Association's guidelines for selective prophylactic central neck dissection (pCND) in children with papillary thyroid carcinoma (PTC) by looking at tumor genetics as a potential way to determine need for surgery.
- Researchers analyzed data from pediatric patients who had post-thyroidectomy oncogene testing and found that tumors with low-invasive alterations showed significantly lower rates of lymph node involvement compared to those with high-invasive alterations.
- The findings suggest that understanding the genetic profile of PTC tumors can help identify pediatric patients who may not need aggressive surgical intervention, thereby reducing unnecessary procedures.
Introduction: Childhood cancer survivors (CCS) are at risk for radiotherapy (RT) late effects, including second malignancies. Optimal screening for differentiated thyroid cancer (DTC) in CCS post-RT remains controversial. We assessed the outcome of thyroid ultrasound (US) surveillance in CCS exposed to RT.
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