Publications by authors named "A Irnstetter"
Background: Aim of this study was to verify a systematic and practical categorization system that allows dynamic classification of pediatric DPLD irrespective of completeness of patient data.
Methods: The study was based on 2322 children submitted to the kids-lung-register between 1997 and 2012. Of these children 791 were assigned to 12 DPLD categories, more than 2/3 belonged to categories manifesting primarily in infancy.
Article Synopsis
- A study aimed to identify factors that predict the long-term success of treatments to eliminate Pseudomonas aeruginosa in cystic fibrosis (CF) patients.
- Researchers analyzed data from CF patients treated between 2005 and 2008, focusing on antibody responses one year post-treatment and their correlation with successful eradication three years later.
- The results showed that specific antibodies could predict treatment outcomes, with a 75% positive and 82% negative predictive value for long-term success, as 60% of patients achieved successful eradication.
Recent case-control studies reported an increased frequency of antibodies against Coxsackie virus (CV) antigens in patients with newly diagnosed type 1 diabetes and during pregnancy in mothers of diabetic offspring, suggesting a role for CV infections in the pathogenesis of type 1 diabetes (T1D). However, it is not known whether CV infections are causally related to the development of islet autoantibodies or merely represent secondary events in subjects already affected with established islet autoimmunity. Therefore we have prospectively evaluated CV infections from birth, prior to and in parallel with the appearance of islet autoantibodies in offspring of parents with T1D.
View Article and Find Full Text PDF