Publications by authors named "A Irimie"
Article Synopsis
- Sarcopenia, characterized by muscle mass loss, is found in up to 68% of rectal cancer patients and negatively affects survival and tumor response, although research on its impact in locally advanced rectal cancer (LARC) is limited.
- A study at the Prof. Dr. Ion Chiricuta Institute of Oncology examined 50 LARC patients who underwent total neoadjuvant treatment (TNT), assessing muscle mass via MRI before and after therapy.
- The findings showed that a lower overall complete response rate (oCR) of 18% was significantly tied to post-treatment sarcopenia, and patients who experienced muscle loss during therapy had worse clinical outcomes and higher instances of cystitis and thrombocytopenia.
Off versus on pump myocardial revascularization in patients with severe asymptomatic carotid stenosis.
J Cardiovasc Surg (Torino)
August 2024
Article Synopsis
- Coronary artery disease is a serious health issue, and the study looks at two different methods of heart surgery called CABG: off-pump and on-pump.
- The researchers found that patients who had the off-pump technique had a much lower chance of having a stroke during or after their surgery compared to those who had the on-pump technique.
- Overall, the study suggests that off-pump CABG is a safer choice for patients with severe carotid stenosis, while still helping them live a long time after the surgery.
Background And Objectives: Rectal cancer accounts for approximately one-third of colorectal cancers, with over 340,000 deaths globally in 2022. Despite advancements in treatment, the five-year overall survival for locally advanced rectal cancer (LARC) remains at 74%, with significant morbidity. B7H3 (CD276), an immune checkpoint protein, plays a role in tumor progression and resistance to therapy, and correlates with poor prognosis in various cancers, including colorectal cancer.
View Article and Find Full Text PDFThe role of magnetic resonance imaging (MRI) in rectal cancer management has significantly increased over the last decade, in line with more personalized treatment approaches. Total neoadjuvant treatment (TNT) plays a pivotal role in the shift from traditional surgical approach to non-surgical approaches such as 'watch-and-wait'. MRI plays a central role in this evolving landscape, providing essential morphological and functional data that support clinical decision-making.
View Article and Find Full Text PDFThe reconstruction of past life based on archaeozoology is a challenging domain that offers a range of valuable details concerning former human and animal populations. Additionally, the ancient era is a source of information for human and veterinary medicine, as well as for other biological sciences. This report highlights a pathological lesion identified during the investigation of a horse skeleton from a pit dated La Tène in Alba County (Romania).
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