Publications by authors named "A Imhoff"
Introduction: Dual specific phosphatases (DUSPs) are mitogen-activated protein kinase (MAPK) regulators, which also serve as drug targets for treating various vascular diseases. Previously, we have presented mechanistic characterizations of DUSP5 and its interaction with pERK, proposing a dual active site.
Methods: Herein, we characterize the interactions between the DUSP5 phosphatase domain and the pT-E-pY activation loop of ERK2, with specific active site assignments.
Purpose: To perform an updated systematic review on the prevalence and morphological characteristics of the anterolateral ligament (ALL) in human cadaveric specimens.
Methods: Medline, Embase, Scopus, and Google Scholar were searched for studies from 2012 to 2024 describing morphology. Study quality was assessed using the Critical Appraisal Skills Programme checklist and Quality Appraisal for Cadaveric Studies scale.
Introduction: Numerous cartilage repair procedures have been developed for focal lesions to minimize suffering and possibly prevent the development of osteoarthritis with a focus on so-called one-step procedures. The aim of this work was to investigate the effects of both focal cartilage defects and a biomaterial (ChondroFiller) on the corresponding articular cartilage.
Materials And Methods: On a friction test stand, 18 porcine osteochondral cylinders were tested in six experimental setups under cyclic loading (33 N) against a friction partner in saline solution.
Article Synopsis
- Osteochondral defects in the knee can cause early arthritis and are more common in young, active people with misaligned bones (called varus malalignment).
- A study looked at how well a combination treatment called Osteochondral Autologous Transfer (OAT) and Valgus High Tibial Osteotomy (HTO) worked for these issues over a long time.
- The researchers found that the treatment had good results, with many patients feeling better and only a small number needing more surgeries after many years.
Amiloride is a U.S. Food and Drug Administration-approved diuretic agent used to treat hypertension and congestive heart failure.
View Article and Find Full Text PDF