Publications by authors named "A Ilhan-Mutlu"
Article Synopsis
- Researchers investigated the prognostic significance of FGF8, ALK, and EML4 as biomarkers in esophageal squamous cell carcinoma (ESCC), focusing on patients who had surgery for the disease.
- The study included 122 patients and utilized fluorescence in situ hybridization (FISH) and immunohistochemistry to analyze gene status and protein expression of FGF8, ALK, and EML4.
- Results indicated that high levels of FGF8 overexpression predicted worse overall survival rates and showed a strong correlation with the alterations of ALK and EML4, suggesting FGF8 might be a target for future therapies.
Introduction: The role of the family history in the development and prognosis of gastroesophageal cancer is a controversially discussed topic as appropriate data from western cohorts are lacking. This study aims to explore its associations with disease and outcome parameters in a large European cohort.
Methods: We retrospectively analyzed self-reported family history in patients with gastroesophageal cancer treated between 1 January 1990 and 31 December 2021 at the Medical University of Vienna.
Article Synopsis
- Brain metastases (BM) are a critical issue for patients with HER2-positive metastatic breast cancer, necessitating better treatment options; the study examined the effectiveness of the antibody-drug conjugate trastuzumab deruxtecan (T-DXd) compared to trastuzumab emtansine.* -
- In the TUXEDO-1 trial involving patients with HER2-positive BC and active BM, the results showed a median progression-free survival (PFS) of 21 months and an overall survival (OS) that had not been reached at 26.5 months of follow-up, indicating positive outcomes for T-DXd.* -
- No new safety concerns emerged throughout the trial, with fatigue being the most reported
Purpose: Gastroesophageal adenocarcinoma is associated with poor prognosis, even in resectable stages. Systemic inflammation plays a key role in cancer progression. Yet, information on prognostic values of systemic inflammatory parameters in European cohorts is scarce.
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