Publications by authors named "A Ihsan Rashan"
Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults in the intensive care unit with suspected hypoxic ischaemic encephalopathy following a cardiac arrest (Mega-ROX HIE).
Crit Care Resusc
June 2024
Article Synopsis
- - The
- Mega-ROX HIE trial
- is an international study designed to compare conservative versus liberal oxygen therapy in adults with hypoxic ischaemic encephalopathy (HIE) after cardiac arrest who are on mechanical ventilation in ICU settings.
- - The
- trial aims to enroll around 4,000 participants
- and will measure all-cause mortality within 90 days from randomization as its primary outcome, alongside several secondary outcomes related to survival and hospital stay.
- - The study is structured to reduce any potential analysis bias by clearly outlining its
- protocol and statistical analysis plan
- , and aims to provide insights into effective oxygen therapies for this population.
Purpose: To systematically review the typology, impact, quality of evidence, barriers, and facilitators to implementation of Quality Improvement (QI) interventions for adult critical care in low- and middle-income countries (LMICs).
Methods: MEDLINE, EMBASE, Cochrane Library and ClinicalTrials.gov were searched on 1st September 2022.
Article Synopsis
- The study aimed to investigate the prevalence and risk factors of frailty among critically ill patients in India, as well as its impact on health outcomes.
- Conducted in 7 ICUs, the research involved 838 patients, finding that nearly 20% were frail, with certain health conditions like malnourishment significantly linked to frailty.
- Results showed frail patients faced higher risks of ICU and in-hospital mortality, and were more likely to require aggressive treatments, indicating frailty is prevalent and detrimental among this patient group.
Background: Improved access to healthcare in low- and middle-income countries (LMICs) has not equated to improved health outcomes. Absence or unsustained quality of care is partly to blame. Improving outcomes in intensive care units (ICUs) requires delivery of complex interventions by multiple specialties working in concert, and the simultaneous prevention of avoidable harms associated with the illness and the treatment interventions.
View Article and Find Full Text PDF