Publications by authors named "A Ihaya"
A 76-year-old man with a history of multiple laparotomies and severe coronary artery disease was referred to our hospital after the sudden development of pain and numbness in the lower extremities. Computed tomography showed a thrombosed abdominal aortic aneurysm and diffuse aortic atherosclerosis; compatible with a "shaggy aorta." A good response to thrombolytic therapy permitted elective scheduling of abdominal aortic surgery after coronary artery bypass grafting.
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- A 34-year-old man with prolonged fever and fatigue was diagnosed with severe bacterial endocarditis affecting his mitral valve, leading to cardiac complications and a bacterial aneurysm in his brain.
- After emergency surgery for cardiac issues, he was treated with antibiotics while closely monitoring the unruptured aneurysm through imaging.
- Remarkably, the aneurysm shrank and eventually disappeared within six weeks, suggesting that the combined approach of surgery and medical management was effective in this complex case.
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- The study explored the effects of the PD-ECGF/TP gene on preventing vein graft failure by inhibiting the migration and proliferation of vascular smooth muscle cells (VSMCs).
- In the experiment involving 68 female rabbits, a poloxamer hydrogel containing various concentrations of trypsin was used to enhance gene transfer efficiency to the vein grafts before assessing intimal thickness over two time points.
- Results indicated that the treating with PD-ECGF/TP significantly reduced intimal thickness and VSMC proliferation compared to controls, demonstrating its potential effectiveness in reducing intimal hyperplasia in vascular grafts.
Background: We previously reported the 2-week benefits of platelet-derived endothelial cell growth factor (PD-ECGF) gene therapy in chronically ischemic myocardium. However, the long-term effects and safety using this gene have not been reported.
Methods: Chronic myocardial ischemia was created in 24 dogs by stenosing the origin of the left anterior descending coronary artery (LAD) using an ameroid constrictor.
Article Synopsis
- PD-ECGF, also known as thymidine phosphorylase, can promote the growth of new blood vessels, potentially benefiting conditions related to chronic limb ischemia, which affects blood flow in the legs.
- In an experiment on rabbits, researchers injected a gene for PD-ECGF/TP into leg muscles after surgically resecting the femoral arteries, resulting in improved blood pressure and vascular growth in the treatment group compared to control groups.
- The study concluded that the overexpression of PD-ECGF/TP significantly enhanced blood vessel formation and limb perfusion, suggesting its potential as a therapeutic option for peripheral arterial disease.