Publications by authors named "A Igoren Guaricci"
How to perform and evaluate a myocardial perfusion imaging by computed tomography.
Eur Heart J Imaging Methods Pract
January 2025
Stress computed tomography perfusion (CTP) delivers a comprehensive evaluation of both the anatomical and functional aspects in a single examination. It stands out as the only non-invasive technique capable of quantifying coronary stenosis and assessing its functional impact, offering a consolidated diagnostic and management approach for patients with confirmed or suspected coronary artery disease (CAD). This very practical review ('How to.
View Article and Find Full Text PDFAim: Computed tomography (CT)-derived extracellular volume fraction (ECV) is a non-invasive method to quantify myocardial fibrosis. Evaluating CT-ECV during aortic valve replacement (AVR) planning CT in severe aortic stenosis (AS) may aid prognostic stratification. This meta-analysis evaluated the prognostic significance of CT-ECV in severe AS necessitating AVR.
View Article and Find Full Text PDFArticle Synopsis
- A variety of conditions, both related to blood flow and not, can lead to ST-segment elevation (STE) on an ECG, one of which is the rare Takotsubo syndrome (TTS) often linked to low calcium levels.
- This paper discusses a unique case of a 75-year-old woman with advanced ovarian cancer, who showed signs on her ECG resembling a heart attack but was actually caused by severe hypocalcemia, with no prior heart issues.
- After ruling out coronary artery disease and providing calcium treatment, her heart function and ECG readings returned to normal, emphasizing the need to consider unusual causes of STE like hypocalcemia in patients with cancer.
Anderson-Fabry disease (AFD) remains a therapeutic challenge despite advances in early diagnosis and the availability of enzyme replacement therapies (ERTs). While early initiation of therapy can mitigate disease progression, resistance mechanisms-such as the development of anti-drug antibodies-limit the efficacy of current treatments, particularly in patients with severe genetic variants. Chaperone therapy provides a targeted option for a subset of patients, yet significant gaps remain in treating those with complete enzyme deficiency.
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