Publications by authors named "A Iezzi"
Article Synopsis
- Lipid-lowering therapies are crucial for preventing atherosclerotic cardiovascular disease (ASCVD) and reducing mortality, with ongoing research into their mechanisms of action using "omics" technologies.
- Pharmacometabolomics specifically examines how these therapies affect metabolic pathways, helping identify variations in treatment responses based on individual factors like disease and environment.
- Integrating pharmacometabolomics with other "omics" data could enhance our understanding of lipid-lowering drugs, paving the way for personalized medicine that improves treatment effectiveness and minimizes side effects.
Article Synopsis
- Human serum albumin (HSA) is the primary plasma protein that acts as an antioxidant, particularly due to a specific cysteine (Cys34) that can form mixed disulfides with low molecular weight thiols, indicating oxidative stress.
- Researchers investigated whether N-Acetylcysteine (NAC) could regenerate the antioxidant form of HSA (HSA-SH) in individuals with unbalanced redox states, using a placebo-controlled crossover study with hypertensive subjects.
- Findings showed that both oral and intravenous NAC significantly reduced the levels of thiolated HSA (Thio-HSA) and increased native HSA-SH, effectively restoring antioxidant capacity, while placebo administration had no effect on these protein levels.
The 15 January 2022 climactic eruption of Hunga volcano, Tonga, produced an explosion in the atmosphere of a size that has not been documented in the modern geophysical record. The event generated a broad range of atmospheric waves observed globally by various ground-based and spaceborne instrumentation networks. Most prominent was the surface-guided Lamb wave (≲0.
View Article and Find Full Text PDFBackground: Nonalcoholic fatty liver disease (NAFLD) or more appropriately, metabolic associated fatty liver disease (MAFLD), is the hepatic manifestation of metabolic syndrome. An imbalance of copper homeostasis has been described in the progression of NAFLD/MAFLD toward NASH/MASH. We were interested in understanding whether the chelating activity of Oleuropein (Ole) was able to improve the copper accumulation and the related pro-oxidant and glycative damage in the liver of mice fed HFD.
View Article and Find Full Text PDFTransthyretin amyloid fibrils alter primary fibroblast structure, function, and inflammatory gene expression.
Am J Physiol Heart Circ Physiol
July 2021
Age-related wild-type transthyretin amyloidosis (wtATTR) is characterized by systemic deposition of amyloidogenic fibrils of misfolded transthyretin (TTR) in the connective tissue of many organs. In the heart, this leads to cardiac dysfunction, which is a significant cause of age-related heart failure. The hypothesis tested is that TTR affects cardiac fibroblasts in ways that may contribute to fibrosis.
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