ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE mice.

The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implicated in modulating the lipid metabolism and reducing cardiovascular disease burden. In this study, we investigated the impact of ASGR1 deficiency (ASGR1 on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N-glycome under the hypercholesterolemic condition in ApoE-deficient mice. After 16 weeks of a western-type diet, ApoE/ASGR1 mice presented lower plasma cholesterol and triglyceride levels compared to ApoE.

Fear appeals, individuals' cognitive-behavioral responses, and willingness to pay for safe water in fluoride-contaminated regions.

In rural areas with high fluoride concentrations in groundwater, affordable and effective de-fluoridation technologies can significantly reduce the likelihood of being affected by fluorosis-related illnesses, such as skeletal fluorosis. This is particularly significant in areas where groundwater is the primary or sole drinking water source, such as the Rift Valley of Tanzania. Despite the availability of technologies, people's use of de-fluoridation devices still needs to be improved.

Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction.

Background: Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial inflammation in the context of HFpEF is not known.

Mineralogical-geochemical study of the anionic competition effect on the octacalcium phosphate reaction into fluorapatite.

The unstable compound octacalcium phosphate (OCP) is one of the crystalline precursors of the apatite mineral series composed by hydroxyapatite, fluorapatite and chlorapatite. The feature of OCP to react into apatite, depending on the media conditions, has been mainly exploited for biomedical applications as bone and tooth substitute material. Recently, some important applications of OCP have been documented: e.

A two-step pH control method to remove divalent metals from near-neutral mining and metallurgical waste drainages by inducing the formation of layered double hydroxide.

A neutral M-rich and M-poor (M = metal) metallurgical waste drainage was used to test a metal removal method based on the precipitation of layered double hydroxide (LDH). The LDH precipitation was induced by adding a salt of Al (trivalent metal missing in the drainage) and maintaining or restoring the pH to a circum-neutral value. The precipitates were characterized by chemical analysis, XRD, ESEM, HRTEM and XAS.