Publications by authors named "A Ianus"
Objectives: Detecting premalignant lesions for pancreatic ductal adenocarcinoma, mainly pancreatic intraepithelial neoplasia (PanIN), is critical for early diagnosis and for understanding PanIN biology. Based on PanIN's histology, we hypothesized that diffusion tensor imaging (DTI) and T2* could detect PanIN.
Materials And Methods: DTI was explored for the detection and characterization of PanIN in genetically engineered mice (KC, KPC).
Article Synopsis
- The choroid plexus (CP) and blood-cerebrospinal fluid-barrier (BCSFB) play a critical role in producing and clearing cerebrospinal fluid, and their dysfunction is linked to neurodegenerative diseases like Alzheimer's disease (AD).
- This study utilized advanced MRI techniques to measure water delivery across the BCSFB in a triple transgenic mouse model of AD, observing significant changes in CP function even before clinical symptoms appear.
- Results indicated increased BCSFB-mediated water delivery in younger mice, with notable behavioral differences arising around 20 weeks, suggesting that CP changes could serve as early biomarkers for AD.
Diffusion-weighted magnetic resonance imaging (DW-MRI) aims to disentangle multiple biological signal sources in each imaging voxel, enabling the computation of innovative maps of tissue microstructure. DW-MRI model development has been dominated by brain applications. More recently, advanced methods with high fidelity to histology are gaining momentum in other contexts, for example, in oncological applications of body imaging, where new biomarkers are urgently needed.
View Article and Find Full Text PDFTemporal Diffusion Ratio (TDR) is a recently proposed dMRI technique (Dell'Acqua et al., proc. ISMRM 2019) which provides contrast between areas with restricted diffusion and areas either without restricted diffusion or with length scales too small for characterisation.
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