[Change in the content of free amino acids in brain tissue and blood plasma of rabbits under the effect of hydrocortisone].

The influence of a single and long term intramuscular hydrocortisone injections on the content of free amino acids was studied in the rabbit brain tissue and blood plasma. It is shown that exogenous hydrocortisone changes the content of certain amino acids in the brain. The changes in the free amino acids spectrum in blood plasma are more significant than in the brain under the hydrocortisone effect.

[Peptide-hydrolase activity in different areas of brain with introduction of hydrocortisone and ACTH].

A single introduction of hydrocortisone is established to evoke an increase in the total activity of acid peptide-hydrolase in most areas of the brain. A single administration of ACTH single and long term administration of hydrocortisone was found to increase the specific activity of acid peptide-hydrolase of the soluble fraction. The specific activity of neutral peptide-hydrolase of the soluble fraction increases with a single administration of ACTH and long term administration of hydrocortisone.