[Effect of hematopoietic and lymphoid cells on the stromal CFU colony formation in rabbit bone marrow cell cultures].

Guinea pig and rabbit bone marrow and splenic cells with increasing cellular density suppress in vitro formation of fibroblast colonies by rabbit bone marrow clonogenic stromal cells. At the same time guinea pig bone marrow and splenic cells produce a stimulating effect on guinea pig bone marrow CFUf, but they are inhibited by rabbit splenocytes, although to a lesser extent than rabbit bone marrow CFUf. Rabbit blood platelets stimulate the growth of bone marrow CFUf of these animals.

[Effects of growth factors on growth of stromal CFU-f in mouse bone marrow cell cultures].

Purified mouse IL-1 at doses 15-100 mu/ml inhibits the growth of stromal clonogenic cells /CFU-f/ both in full bone marrow cell cultures /F-cultures/ and in adherent bone marrow cell cultures /A-cultures/. Rec. human TNF-alpha inhibits growth of these cells at doses greater than 50 u/ml, but stimulates it /in 1.