Population Digital Health: Continuous Health Monitoring and Profiling at Scale.

This paper introduces population digital health (PDH)-the use of digital health information sourced from health internet of things (IoT) and wearable devices for population health modeling-as an emerging research domain that offers an integrated approach for continuous monitoring and profiling of diseases and health conditions at multiple spatial resolutions. PDH combines health data sourced from health IoT devices, machine learning, and ubiquitous computing or networking infrastructure to increase the scale, coverage, equity, and cost-effectiveness of population health. This contrasts with the traditional population health approach, which relies on data from structured clinical records (eg, electronic health records) or health surveys.

Microbial biosensors for diagnostics, surveillance and epidemiology: Today's achievements and tomorrow's prospects.

Microbial biosensors hold great promise for engineering high-performance, field-deployable and affordable detection devices for medical and environmental applications. This review explores recent advances in the field, highlighting new sensing strategies and modalities for whole-cell biosensors as well as the remarkable expansion of microbial cell-free systems. We also discuss improvements in robustness that have enhanced the ability of biosensors to withstand the challenging conditions found in biological samples.

The internal decay of wood is driven by the interplay between foraging Magellanic woodpeckers and environmental conditions.

Although woodpeckers are known to forage in decaying trees, their contribution to internal wood decay is not well known. In this sense, non-destructive techniques for structural wood degradation provide an opportunity to quantitatively assess the role of woodpeckers in tree decay. We used sonic tomography to test that the trunks of living trees pecked by Magellanic woodpeckers show pronounced decay, which accelerates under environmental conditions favorable to wood-decaying fungi.

Identification of targetable epigenetic vulnerabilities in uveal melanoma.

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, which preferentially metastasizes to the liver in approximately half of all cases. Metastatic UM is notoriously resistant to therapy and is almost uniformly fatal. UM metastasis is most strongly associated with mutational inactivation of the tumor suppressor gene.