Anticancer Activity In Vitro of Sulfated Polysaccharides from the Brown Alga .

Sulfated polysaccharides SpvF1, SpvF2, SpvF3, and SpvF4 from the brown alga collected north of Hon Do (Nha Trang Bay, Vietnam) were isolated and studied. The structure of the obtained polysaccharide was studied using chemical methods and NMR spectroscopy. Fucoidans were low-sulfated (SpvF1, SpvF2) and medium-sulfated (SpvF3, SpvF4) heterogeneous polysaccharides.

Rational (supra)molecular design and catalytic activity of cage-like Cu-based phenylsilsesquioxanes.

An extended (, 19 distinct species) family of cage-like Cu-phenylsilsesquioxanes allowed us to accentuate the general regularities behind their structural organization. Influencing factors, namely the (i) size of external alkali metal ions (from Li to Cs) and (ii) nature of bridging linkers (including the smallest possible ones, like a water molecule) on the self-assembly/supramolecular assembly of such Cu-building blocks have been thoroughly explored. A CuK-based complex has been evaluated as a precatalyst in the oxidation of alkanes (cyclohexane, -heptane, methylcyclohexane) and alcohols.

A Family of Hexacopper Phenylsilsesquioxane/Acetate Complexes: Synthesis, Solvent-Controlled Cage Structures, and Catalytic Activity.

Convenient self-assembly synthesis of copper(II) complexes via double (phenylsilsesquioxane and acetate) ligation allows to isolate a family of impressive sandwich-like cage compounds. An intriguing feature of these complexes is the difference in the structure of a pair of silsesquioxane ligands despite identical (Cu) nuclearity and number (four) of acetate fragments. Formation of particular combination of silsesquioxane ligands (cyclic/cyclic vs condensed/condensed vs cyclic/condensed) was found to be dependent on the synthesis/crystallization media.

The Discovery of the Fucoidan-Active Endo-1→4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant Activity.

Sulfated polysaccharides of brown algae, fucoidans, are known for their anticoagulant properties, similar to animal heparin. Their complex and irregular structure is the main bottleneck in standardization and in defining the relationship between their structure and bioactivity. Fucoidan-active enzymes can be effective tools to overcome these problems.

Structure and Metabolically Oriented Efficacy of Fucoidan from Brown Alga in the Model of Colony Formation of Melanoma and Breast Cancer Cells.

This work reports the detailed structure of fucoidan from (2SmF2) and its ability to potentiate the inhibitory effect of glycolysis inhibitor 2-deoxy-d-glucose (2-DG). 2SmF2 was shown to be sulfated and acetylated galactofucan containing a main chain of alternating residues of 1,3- and 1,4-linked α-l-fucopyranose, fucose fragments with monotonous 1,3- and 1,4-type linkages (DP up to 3), α-d-Gal-(1→3)-α-L-Fuc disaccharides, and 1,3,4- and 1,2,4-linked fucose branching points. The sulfate groups were found at positions 2 and 4 of fucose and galactose residues.