[Changes in the lipid content of the blood and erythrocyte membrane in patients with IHD under the influence of quantum therapy].

Laser therapy of coronary patients significantly diminished total cholesterol, low and very low density lipoproteins, triglycerides and atherogenic index persisting for 3-6 months. Primary changes in the structure of the lipid bilayer of a red cell membrane in response to laser radiation are considered to be an effect of the physical factor characterized by activation of lipid peroxidation, phospholipolysis, by growth of membrane cholesterol content (phase I). Mobilization of the adaptive mechanisms was accompanied by positive shifts in the structure pattern of a biomembrane with return to initial condition by the end of the therapy course (phase II).

[Membrane-active preparations as correctors of the nephrotoxicity of gentamicin].

At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity.