[Experimental substantiation of recombinant epidermal growth factor use efficacy in the treatment of wounds of mucosal membrane of oral cavity in the immunodeficiency].

In experiment on rats in the immunodeficiency the use of recombinant epidermal growth factor was substantiated that let to speed up reparative regeneration at concentration 500 ppb/l drinking water.

[Influence of allogenic and autologic multipotent stromal cells of adipose tissue upon bone tissue regeneration in the rabbit mandible angle defect].

Reconstructive surgery often collides with complicated task of defect recovery in the situation of deficit of maxillofacial skeleton tissues, that leads to necessary search of accessible cells source with osteogenic potentials and proper substrate for cell transplantation. In the study the regeneratory potential of stromal cells of adipose tissue was tested in the rabbit model of mandible through angle defect. Cells of allogenic and autologic nature stimulated reparative osteogenesis but their influence upon bone matrix maturation was different.

[Use of mesenchymal stem cells for reparative processes activation in bone jaw tissue in experimental conditions].

In experiment on 12 Chinchilla rabbits dynamics of reparative regeneration was studied at the terms 2 and 4 months. Bone defect in mandible corner was closed by osteoplastic material Gapkol which was covered from inside by allogenic or autologic stem cells received from rabbit adipose tissue. The results of the ray tracing methods of study were verified by SEM and histological methods.

[Screening study methods use for substantiation of immune modulating therapy of hypergic inflammatory process in maxillofacial region].

With the help of flow cytometry it was shown that for patients with hypergic inflammatory process in maxillofacial region the reduction of lymphocytes relative number was typical as well as their absolute number reduction. Direct and very strong correlation was established between absolute lymphocytes number in peripheral blood and absolute number of CD3 and CD4 lymphocytes subpopulations by correlation analyses. The reduction of absolute lymphocytes number in peripheral blood let speak with more probability about the reduction of the number of CD3 and CD4 lymphocytes subpopulations and diagnose secondary immune deficit.