Objective: Idiopathic central precocious puberty (CPP) precipitates epiphyseal fusion of growth plates in long bones, leading to reduced adult stature. Gonadotropin-releasing hormone analogues (GnRHa) are the treatment of choice for idiopathic CPP, but their benefit on height gain is unclear. We aimed to elucidate the effects of GnRHa treatment on adult height in girls with idiopathic CPP.
View Article and Find Full Text PDFUntil quite recently, Conceptual DFT (CDFT) was mainly based on the energy functional, [,], where the number of electrons and the external potential are state variables. One of the strengths of CDFT, however, is the ease with which additional and/or different state variables can be incorporated. Here, the incorporation of new variables-namely temperature and external fields-is discussed, outlining the motivation for these extensions, sketching their theoretical/computational context, and presenting some elucidative examples.
View Article and Find Full Text PDFChemical systems displaying directional motions are relevant to the operation of artificial molecular machines. Herein we present the functioning of a molecule capable of transporting a cyclic species in a preferential direction. Our system is based on a linear, non-symmetric, positively charged molecule.
View Article and Find Full Text PDFObjectives: Latinos living in the US are disproportionately impacted by Alzheimer's disease and related dementias (ADRD). To develop culturally-informed interventions, a first step is engaging with key stakeholders. The present study aimed to explore perspectives on brain health and aging among middle-aged Latinos living in Chicago, IL.
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