Modern combined approach to the surgical treatment of patients with post-traumatic tympanic membrane perforation due to blast injuries and eustachian tube dysfunction.

Objective: Aim: To improve the effectiveness of surgical treatment for patients with post-traumatic tympanic membrane perforations and concurrent Eustachian tube dysfunction through simultaneous combined surgical methods.

Patients And Methods: Materials and Methods: We analyzed clinical and functional outcomes of 35 patients (mean age: 34 ± 10,5 years) with tympanic membrane perforations caused by acoustic and blast injuries. The patients were divided into two groups: the first group (n=17) underwent only tympanoplasty type 1, while the second group (n=18) underwent simultaneous septoplasty, inferior turbinectomy, and tympanoplasty with prolonged middle ear ventilation using a subanular Silverstein tube.

phage therapy candidates from Sphae: An automated toolkit for predicting sequencing data.

Motivation: Phage therapy is a viable alternative for treating bacterial infections amidst the escalating threat of antimicrobial resistance. However, the therapeutic success of phage therapy depends on selecting safe and effective phage candidates. While experimental methods focus on isolating phages and determining their lifecycle and host range, comprehensive genomic screening is critical to identify markers that indicate potential risks, such as toxins, antimicrobial resistance, or temperate lifecycle traits.

Synergistic neurological threat from Сu and wood smoke particulate matter.

Trace metal Cu and carbonaceous airborn particulate matter (PM) are dangerous neuropollutants. Here, the ability of Cu to modulate the neurotoxicity caused by water-suspended wood smoke PM preparations (SPs) and vice versa was examined using presynaptic rat cortex nerve terminals. Interaction of Cu and SPs, changes of particle size and surface properties were shown in the presence of Cu using microscopy, DLS, and IR spectroscopy.

Butyric acid and prospects for creation of new medicines based on its derivatives: a literature review.

The widespread use of antimicrobials causes antibiotic resistance in bacteria. The use of butyric acid and its derivatives is an alternative tactic. This review summarizes the literature on the role of butyric acid in the body and provides further prospects for the clinical use of its derivatives and delivery methods to the animal body.

Multipollutant reciprocal neurological hazard from smoke particulate matter and heavy metals cadmium and lead in brain nerve terminals.

Heavy metals, Cd and Pb, and carbonaceous air pollution particulate matter are hazardous neurotoxicants. Here, a capability of water-suspended smoke particulate matter preparations obtained from poplar wood (WPs) and polypropylene fibers (medical facemasks) (MPs) to influence Cd/Pb-induced neurotoxicity, and vice versa, was monitored using biological system, i.e.