Publications by authors named "A I Staff"
Article Synopsis
- - The study investigates the potential link between human papillomavirus (HPV) infections during pregnancy and negative pregnancy outcomes, such as hypertensive disorders, gestational diabetes, and low birth weight newborns.
- - Data were collected from pregnant women in Norway and Sweden, examining urine samples for various HPV genotypes and analyzing their association with adverse outcomes using statistical models.
- - Results showed that 40% of participants had at least one HPV genotype, with 24% being high-risk types, indicating a notable prevalence, although the relationship between HPV and adverse outcomes is still being explored.
Introduction: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from parental incompatibility in human platelet antigens (HPA) and subsequent maternal sensitization. The HPA-1a epitope is also expressed on placental tissue. Chronic placental inflammation and lower birth weight is observed more often in HPA-1a alloimmunized pregnancies, suggesting a placental component in the pathophysiology of FNAIT.
View Article and Find Full Text PDFBackground: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step toward protecting mother and child from this syndrome and increased risk of cardiovascular disease later in life. However, effective early predictive tests and therapies for preeclampsia are scarce.
View Article and Find Full Text PDFFoetal cells are detectable in women decades postpartum, a state termed foetal microchimerism. The interplay between these semi-allogeneic foetal cells and the mother could be affected by genetic mismatches in the HLA loci. Here, we relate HLA allele and molecular mismatch values to the presence and quantity of foetal microchimerism in the maternal circulation during pregnancy and postpartum.
View Article and Find Full Text PDFBackground: Sentinel lymph node biopsy (SLN) is increasingly used for surgical staging of endometrial carcinoma.
Objective: To estimate the effect and cost-effectiveness of the implementation of an SLN algorithm for surgical staging in patients with intermediate- and high-risk endometrial carcinoma compared with lymphadenectomy.
Methods: We performed a model-based, cost-effectiveness analysis using primary data from a tertiary referral hospital that included 829 patients with endometrial carcinoma undergoing surgical staging.