[Management of patients with treatment-resistant neovascular age-related macular degeneration].

Purpose: This study evaluates the efficacy of intravitreal injections (IVI) of faricimab in patients with neovascular age-related macular degeneration (nAMD) and retinal pigment epithelium detachment (RPED) resistant to other anti-VEGF agents.

Material And Methods: The study included 61 patients (61 eyes) with nAMD previously treated with aflibercept and/or brolucizumab IVIs. Three groups were formed: group 1 received aflibercept IVI (32 eyes), group 2 received brolucizumab IVI (14 eyes), and group 3 received aflibercept followed by brolucizumab IVI (15 eyes).

Enhancement of Water Uptake in Composite Superabsorbents Based on Carboxymethyl Cellulose Through Porogen Incorporation and Lyophilization.

Carboxymethyl cellulose sodium salt (CMC)-based superabsorbents are promising materials for the development of agricultural matrices aimed at water management and slow-release fertilizer production. However, an increase in the CMC content tends to reduce their water-absorbing capacity. This study aims to develop a cost-effective method for producing eco-friendly superabsorbents with enhanced water-absorbing capacity by incorporating a porogen and employing lyophilization.

Polarization squeezing in chalcogenide fibers.

We experimentally demonstrate the generation of polarization-squeezed light in a short piece of solid-core chalcogenide (ChG) (AsS) fiber via the Kerr effect for femtosecond pulses at 1.56 µm. Directly measured squeezing of -2.

Novel Hybrid Catalysts of Cysteine Proteases Enhanced by Chitosan and Carboxymethyl Chitosan Micro- and Nanoparticles.

Micro- and nanoparticles of chitosan and carboxymethyl chitosan were synthesized, both with and without ascorbic acid. Methods were developed to form complexes between these micro- and nanoparticles and plant proteases-ficin, papain, and bromelain. It was demonstrated that the activity of cysteine protease complexes with carboxymethyl chitosan micro- and nanoparticles was higher compared to those with chitosan micro- and nanoparticles.

Impact of global environmental changes on the range contraction of Eurasian moose since the Late Pleistocene.

Climatic oscillations are considered primary factors influencing the distribution of various life forms on Earth. Large species adapted to cold climates are particularly vulnerable to extinction due to climate changes. In our study, we investigated whether temperature increase since the Late Pleistocene and the contraction of environmental niche during the Holocene were the main factors contributing to the decreasing range of moose (Alces alces) in Europe.