Publications by authors named "A I Sahyoun"
Osteoporosis, a condition marked by the loss of bone density and mass, affects individuals of all ages. However, it becomes more prevalent and severe with aging, increasing the risk of fractures and other health complications. Recent research has highlighted a link between osteoporosis and periodontitis, a chronic gum disease, as both conditions involve excessive bone loss that can lead to significant oral health problems if untreated.
View Article and Find Full Text PDFArticle Synopsis
- Dyslipidemia is a key risk factor for cardiovascular diseases, and current treatments primarily aim to lower LDL cholesterol levels to prevent conditions like atherosclerosis and myocardial infarction.
- Homozygous Familial Hypercholesterolemia (HoFH) results from mutations in the LDL receptor, leading to very high LDL cholesterol levels, which often do not respond well to standard statin therapy.
- Lomitapide, a microsomal triglyceride transfer protein inhibitor, has been approved for HoFH treatment; it effectively lowers LDL-C levels without affecting the LDL receptor and has been shown to reduce LDL-C by more than 50% in resistant cases.
The oral microbiome is a diverse ecosystem containing a community of symbiotic, commensal, and pathogenic microorganisms. One key microorganism linked to periodontal disease (PD) is (), a Gram-negative anaerobic bacterium known to have several virulence factors that trigger inflammation and immune evasion. On the other hand, (), a symbiotic bacterium, has been recently shown to play an important role in mitigating inflammation and reducing periodontal damage.
View Article and Find Full Text PDFThis study examines the associations between working night shifts and various outcomes, including sleep patterns, healthcare workers' sleep quality, and physical, mental, and social well-being. A descriptive cross-sectional study was conducted, where the findings revealed that night shift healthcare workers experienced poor sleep quality and pattern. In addition, night shift healthcare workers were more likely to express their intent to leave, the impact of work on their social lives, and a low level of job satisfaction.
View Article and Find Full Text PDFArticle Synopsis
- Different levans, which are polysaccharides with varying structures and molecular weights, were produced and studied for their functional and health benefits.
- The study used levansucrases from two bacteria and confirmed the structures of β-(2, 6) levans, categorizing them into high molecular weight (HMW), low molecular weight (LMW), and mixed types.
- Findings indicated that LMW levans had the best foaming properties, while HMW levans excelled in emulsion stability, and both HMW and mixed levans demonstrated anti-inflammatory effects in cell studies by reducing pro-inflammatory cytokines.