Publications by authors named "A I Roach"
Background: Development of a paediatric palliative care child and family centred outcome measure is a priority for health care professionals, researchers and advocates. It is methodologically challenging to develop a measure relevant for such a heterogenous population with complex needs. Involving children in measuring development is vital.
View Article and Find Full Text PDFProlonged post-operative hydrocodone usage due to psychotropic drug interaction.
Drug Metab Pers Ther
December 2024
Objectives: To explore pain outcomes in patients prescribed hydrocodone and psychotropic medications with or without CYP2D6 inhibition activity.
Methods: Patients hospitalized for lower/limited upper extremity injuries who were prescribed hydrocodone alongside a psychotropic medication were considered for this study (n=224). A subset of these patients (n=178) was prescribed a psychotropic medication known to inhibit CYP2D6, while the remainder (n=46) were prescribed psychotropic medications without CYP2D6 inhibition activity.
δ-Aminolevulinic acid (ALA) dehydratase (ALAD) deficient porphyria (ADP) is an extremely rare form of porphyria, with only eight documented cases. Herein, we report the second known case of ADP in the Western hemisphere and third case with infantile onset of symptoms. A male neonate presented on day three of life with profound hypotonia, pinpoint pupils, absent deep tendon reflexes, and anemia.
View Article and Find Full Text PDFArticle Synopsis
- Discipline is vital for parenting, and while time-out is a common strategy with solid evidence, it faces criticism regarding its effects on emotional development, especially for children with past adversities.
- This study involved 474 Australian primary caregivers of children aged 6-8 and examined how time-out's implementation relates to parent-child attachment and child mental health, factoring in experiences of adversity.
- Results indicated that when used appropriately, time-out can improve mental health and attachment, especially for children facing adversity, suggesting that misinformation about time-out should be addressed to promote child well-being effectively.
Article Synopsis
- Pathological mutations in the Trk-fused gene (TFG) are linked to neurodegenerative diseases, particularly hereditary spastic paraplegia (HSP), causing lower limb issues.* -
- Researchers used X-ray crystallography and cryo-electron microscopy to reveal how TFG forms octameric ring complexes, crucial for its function.* -
- Mutations from HSP patients disrupt the stability of these complexes, leading to neurodegenerative effects, but different mutations have varying impacts, indicating multiple mechanisms of disease progression.*