Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates.

Intracellular liquid-liquid phase separation (LLPS) of proteins and nucleic acids is a fundamental mechanism by which cells compartmentalize their components and perform essential biological functions. Molecular simulations play a crucial role in providing microscopic insights into the physicochemical processes driving this phenomenon. In this study, we systematically compare six state-of-the-art sequence-dependent residue-resolution models to evaluate their performance in reproducing the phase behaviour and material properties of condensates formed by seven variants of the low-complexity domain (LCD) of the hnRNPA1 protein (A1-LCD)-a protein implicated in the pathological liquid-to-solid transition of stress granules.

Think-Aloud Testing of a Companion App for Colonoscopy Exams: Usability Study.

Background: Colonoscopies, are vital for initial screening, follow-ups, surveillance of neoplasia, and assessing symptoms like rectal bleeding. Successful colonoscopies require thorough colon preparation, but up to 25% fail due to poor preparation. This can lead to longer procedures, repeat colonoscopies, inconvenience, poorer health outcomes, and higher costs.

Entanglement Generation in Weakly Driven Arrays of Multilevel Atoms via Dipolar Interactions.

We investigate the driven-dissipative dynamics of multilevel atomic arrays interacting via dipolar interactions at subwavelength spacings. Unlike two-level atoms in the weakly excited regime, multilevel atoms can become strongly entangled. The entanglement manifests as the growth of spin waves in the ground-state manifold and survives after turning off the drive.

Non-Surgical Novel Technique for Correction of Palpebromalar Groove (Tear Valley Deformity) and Extended Area: The Matador Stab.

Introduction: The tear valley deformity presents unique challenges in aesthetic correction. The Matador Stab technique and its modification introduce a novel approach to address this anatomical complexity.

Methods: A prospective study was conducted on 198 patients presenting with tear valley deformities.

Measuring Bipartite Spin Correlations of Lattice-Trapped Dipolar Atoms.

We demonstrate a bipartition technique using a superlattice architecture to access correlations between alternating planes of a mesoscopic array of spin-3 chromium atoms trapped in a 3D optical lattice. Using this method, we observe that out-of-equilibrium dynamics driven by long-range dipolar interactions lead to spin anticorrelations between the two spatially separated subsystems. Our bipartite measurements reveal a subtle interplay between the anisotropy of the 3D dipolar interactions and that of the lattice structure, without requiring single-site addressing.