Publications by authors named "A I Pick"
Efficient regeneration of NAD remains a significant challenge for oxidative biotransformations. In order to identify enzymes with higher activity and stability, a panel of NADH oxidases (Nox) was investigated in the regeneration of nicotinamide cofactors for the oxidation of hydroxymethyl furfural (HMF) to 5-hydroxymethyl-2-furancarboxylic acid (HMFCA). We present novel Nox that exhibit remarkable catalytic activities, elevated thermal and pH stabilities, and higher intrinsic flavin loadings, thus eliminating the need for external flavin addition.
View Article and Find Full Text PDFObjective: In response to the high prevalence and morbidity associated with long COVID (LC), outpatient rehabilitation programmes were created across jurisdictions. We aimed to characterize baseline symptoms and impairments of patients attending outpatient LC rehabilitation.
Design: This study was a retrospective quality-improvement analysis.
The protracted form of COVID-19 known as 'long covid' was first described in 2020. Its symptoms, course and prognosis vary widely; some patients have a multi-system, disabling and prolonged illness. In 2021, ring-fenced funding was provided to establish 90 long covid clinics in England; some clinics were also established in Scotland and Wales.
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- Dementia presents significant challenges for individuals and their caregivers, often leading to social isolation and difficulty accessing necessary support, prompting the exploration of social prescribing (SP) as a means to enhance resource access.
- The study will conduct a systematic review of existing SP interventions for people living with dementia and their caregivers, utilizing a thorough methodology across multiple scientific databases and an iterative logic model approach to understand current practices and needs.
- No ethical approval is needed since the review will only analyze secondary data, and results will be shared through peer-reviewed publications and presentations to relevant stakeholders.
The novel photoswitchable ligand 3,3'-Azobenz(metPA) (1) is used to prepare a [Cu(1)](BF) metallocycle (2), whose photoisomerization was characterized using static and time-resolved spectroscopic methods. Optical studies demonstrate the highly quantitative and reproducible photoinduced cyclic E/Z switching without decay of the complex. Accordingly and best to our knowledge, [Cu(1)](BF) constitutes the first reversibly photoswitchable (3d)-metallocycle based on azobenzene.
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