Loss of HNRNPK During Cell Senescence Linked to Reduced Production of CDC20.

Cellular senescence is a complex biological response to sublethal damage. The RNA-binding protein HNRNPK was previously found to decrease prominently during senescence in human diploid fibroblasts. Here, analysis of the mechanisms leading to reduced HNRNPK abundance revealed that in cells undergoing senescence, mRNA levels declined transcriptionally and full-length HNRNPK protein was progressively lost, while the abundance of a truncated HNRNPK increased.

Nanofibrous Peptide Hydrogels Leveraging Histidine to Modulate pH-Responsive Supramolecular Assembly and Antibody Release.

In this work, we investigate the pH-responsive behavior of multidomain peptide (MDP) hydrogels containing histidine. Small-angle X-ray scattering confirmed that MDP nanofibers sequester nonpolar residues into a hydrophobic core surrounded by a shell of hydrophilic residues. MDPs with histidine on the hydrophilic face formed nanofibers at all pH values tested, but the morphology of the fibers was influenced by the protonation state and the location of histidine in the MDP sequence.

Microwave-Assisted Cobalt-Catalyzed Synthesis of Quinazolinones via Acceptorless Dehydrogenative Coupling under Neat Condition.

Herein, we present a sustainable and atom-economical approach for the synthesis of quinazolinones via acceptorless dehydrogenative coupling (ADC) using earth-abundant Co-salt, (CoCl2) as the catalyst under neat condition. This method is distinguished by its green credentials, like, solvent-free, microwave-assisted heating, cost-effective, use of renewable alcohols, and generating only H2 and water as byproducts. Remarkably, this protocol achieves quinazolinone synthesis without the need for external ligands, oxidants, or additional additives.

Host-seeking and exophilic-endophilic activities of Culicoides spp. (Diptera: Ceratopogonidae) with notes on two trapping methods.

Host-seeking behavior of Culicoides species was examined from 2018 to 2019 in West Bengal, India, which elucidated diel activity, feeding success, attack rate, biting rate, and preferential landing of adult Culicoides on the cattle. A comparative assessment was done between the light trap and the aspirator. The host-seeking experiment involved a substantial timeframe of 297 h of catch collections over 27 nights.

Comparative Evaluation of Obturation Quality Using Three Different Obturation Techniques in Primary Teeth: A Conebeam Computed Tomography Analysis: Study.

Context: Pulpectomy is recommended for primary teeth when both the coronal and radicular pulp tissues are irreversibly damaged. Biomechanical preparation of root canals is essential for the success of endodontic treatment. Achieving the optimal length during obturation while minimizing voids and ensuring a hermetic seal is crucial for the success of pulpectomy procedures.