Nutraceutical Impact of Pumpkin Seed Oil on Expression Levels of EZH-2 and KRT-14 Genes against DSS-induced Inflammatory Bowel Disease in the Rat Model.

Inflammatory bowel disease is a collection of intestinal disorders that cause inflammation in the digestive tract. Prolonged inflammation in the gastrointestinal tract is a major risk factor for colorectal cancer. The objective of this study was to fucus on gene expression levels of (KRT-14; associated with epithelial cell integrity) and enhancer of zeste homolog-1 (EZH-2; involved in cellular proliferation) in a IBD rat model in order to rule out impact of nutraceuticals (pumpkin seed oil; PSO) as a complementary approach to conventional treatments of IBD.

Understanding malaria treatment patronage from informal healthcare providers in Nigerian urban settlements: insights from community members and providers.

Background: Informal Healthcare Providers (IHCPs), including Proprietary Patent Medicine Vendors (PPMVs), drug peddlers, traditional healers, and herbal drug sellers are often the first choice for malaria treatment, especially in urban slums. Unplanned urbanization significantly impacts malaria transmission by creating cities with inadequate safety nets and healthcare access, increasing reliance on IHCPs. While the World Health Organization recognizes IHCP's crucial role and emphasizes integrating them into formal healthcare for improved malaria care, they lack requisite training in malaria management and operate outside official regulations, raising concerns about the quality of care they provide.

Impact of rhizobacterial inoculation in plant growth medium to mitigate lead stress in Tomato (Solanum lycopersicum L.).

This study investigates the effects of lead stress on tomato plants and explores the potential role of plant growth-promoting rhizobacteria (PGPR) to alleviate this stress. The experiment was conducted in pots, introducing varying lead levels (0, 100, 200, 300, 400, and 500 mg kg⁻¹) using lead nitrate. For rhizobacterial inoculation, pre-characterized LTPGP strains S5 Pseudomonas fluorescens A506 and S10 Pseudomonas fluorescens LMG 2189 were used.

Optimal design of tilt integral derivative controller for a boost converter based on swarm-inspired algorithms.

This article proposes a novel dual-loop control (DLC) method with a Tilt Integral Derivative (TID) Controller for output voltage regulation and inductor current regulation in a boost converter. The TID controller is designed with the aid of swarm inspired algorithms, particularly Artificial Bee Colony (ABC) and Salp Swarm Optimization (SSO). The TID Controller is a robust, and feedback type of controller and belongs to the family of fractional order controllers.

Formation of alginate gel stabilized silica nanoparticles for encapsulation and topical delivery of minoxidil.

Silica nanoparticles-embedded smart-gels are efficient drug carrier systems due to their structural flexibility, high porosity, and ease of formulation development. Herein, the extent of interaction of minoxidil (MXD), a potent vasodilator prodrug, with silica nanoparticles (SiNPs) and alginate (ALG) was investigated. The SiNPs were prepared by extracting silica from rice husk ash, and these SiNPs were further used to prepare MXD-loaded-SiNPs (MXD-SiNPs) by loading them with an appropriate amount of MXD.