Dynamics of the content of reactive oxygen species and the state of the glutathione system in the oral cavity during subchronic intoxication wuth the fungicide thiram and its antioxidant correction.

Thiram is a dithiocarbamate derivative, which is used as a fungicide for seed dressing and spraying during the vegetation period of plants, and also as an active vulcanization accelerator in the production of rubber-based rubber products. In this study the content of reactive oxygen species (ROS) and the state of the glutathione system have been investigated in the oral fluid and gum tissues of adult male Wistar rats treated with thiram for 28 days during its administration with food at a dose of 1/50 LD50. Thiram induced formation of ROS in the oral cavity; this was accompanied by an imbalance in the ratio of reduced and oxidized forms of glutathione due to a decrease in glutathione and an increase in its oxidized form as compared to the control.

[The beta-adrenoreceptors of the cerebral cortex in rat pups after exposures altering the noradrenaline level].

Elevation of noradrenaline level in the brain cortex of 7-day old rats induced by prenatal corticosterone administration was accompanied by a decrease in beta-adrenoreceptor density determined by specific [3H]dihydroxyalprenolol binding. Affinity of receptors to the ligand remained unchanged. Injections to 4-6-day old rats of alpha-methyl-p-tyrosine that blocks catecholamine synthesis resulted in a decreased noradrenaline content and increased beta-adrenoreceptor density in the brain cortex of 7-day old rats.

[The ontogeny of the alpha 2- and beta-adrenoreceptors in the brain following exposure to corticosterone during intrauterine development].

Ontogenesis of alpha 2- and beta-adrenoreceptors in brain cortex of rats after corticosterone injections to their mothers on days 16 and 18 days of gestation was studied using 3H-clonidine and 3H-dihydroaoprenolol binding. After corticosterone treatment the level of beta-adrenoreceptors was decreased on day 7 but increased on day 16 after birth; On the contrary, catecholamine levels and biosynthesis determined previously were increased in the first and decreased in the second age group. beta-adrenoreceptors' density and noradrenaline level during other periods of pre- and postnatal development remained unchanged.