[Aspects for data mining implementation in gerontology and geriatrics].

Current challenges facing theory and practice in ageing sciences need new methods of experimental data investigation. This is a result as of experimental basis developments in biological research, so of information technology progress. These achievements make it possible to use well proven in different fields of science and engineering data mining methods for tasks in gerontology and geriatrics.

[Statistical analysis of links between cancer and associated diseases].

We investigate dependencies between cancer morbidity and associated diseases. A statistical method that yields blocks of diseases with most significant influence on the cancer morbidity is described. Based on USA data about cause-specific mortality we select diseases which have maximum differences between distributions of associated diseases in a group of people which had cancer or died from it and a group of people which didn't have cancer.

[Basic principles of creation of multilevel multistage mathematical model of aging].

Current knowledge on the aging allows to elaborate approaches to the creation of multilevel model of multistage of human aging taking into consideration events during the aging at various levels of integration: molecular, cellular, tissue, organ, systemic, organism. The present paper have deals with main states of the mathematical model of multistage aging, principles of its construction, applicability and evaluation of its prognostic power. There are 3 levels of integrative systems: homeostatic (organismal), systemic and cellular-molecular.

[Investistigation of the role of heterogenety individual radiosensitivity in estimation of radiation indused ageing].

The influence of heterogeneity in individual radiosensitivity on estimation of ageing using survival curve is considered. Quadratic deviation of the rate of ageing from the true value in estimated by imitation modeling techniques. The Gompertz model for spontaneous mortality and gamma-frailty model for heterogeneity are used.

[Mathematical modelling and aging: a program for scientific research].

Problems of mathematical modelling are discussed in connection with a study of aging and longevity. The directions of investigation are presented in which the greatest effect of the application of mathematical modelling for solving the problem of radical human life prolongation is expected.