Publications by authors named "A I Matveev"
Article Synopsis
- Ribavirin and its modified versions were found to have a significant effect on inhibiting the growth of cancer cells, particularly leukemia cells.
- Researchers synthesized several derivatives of ribavirin, specifically targeting their structural positions to evaluate their antiproliferative and antimicrobial properties, showing that some were effective against both Gram-positive and Gram-negative bacteria.
- The most promising derivative, n-decyloxymethyl, was shown to kill leukemia cells at low doses by disrupting cell cycle progression and potentially inhibiting critical cellular processes involved in cancer growth.
Article Synopsis
- The current tests for identifying TB infection include the Tuberculin Skin Test (TST) and interferon-gamma release assays (IGRA), but access and implementation issues limit their use.
- Novel skin tests such as Diaskintest and C-TST show potential for better scalability and accuracy, though evidence on their economic impact is still lacking.
- Systematic reviews indicated that while costs for TBST were generally lower than TST and IGRA, there is limited high-quality evidence for TBST, and the existing studies on TST and IGRA lean towards high-income settings without clear economic consensus.
Omsk hemorrhagic fever virus (OHFV) is a member of the tick-borne encephalitis virus (TBEV) complex of the family. Currently, there are no data on the cross-reactivity of antibodies to the NS1 proteins of OHFV and TBEV. Such data are of major interest for monitoring viral encephalitis of unknown etiology due to the increasing geographical distribution of OHFV.
View Article and Find Full Text PDFAntibodies are protein molecules whose primary function is to recognize antigens. However, recent studies have demonstrated their ability to hydrolyze specific substrates, such as proteins, oligopeptides, and nucleic acids. In 2023, two separate teams of researchers demonstrated the proteolytic activity of natural plasma antibodies from COVID-19 convalescents.
View Article and Find Full Text PDFThe rapid development of vaccines is a crucial objective in modern biotechnology and molecular pharmacology. In this context, conducting research to expedite the selection of a potent immunogen is imperative. The candidate vaccine should induce the production of antibodies that can recognize the immunogenic epitopes of the target protein, resembling the ones found in recovered patients.
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