Preliminary evidence for genetic anticipation in Crohn's disease.

Background: The term genetic anticipation is used to describe earlier onset of disease, increased severity, or both, in succeeding generations of families affected by a particular disease. This process has been linked with expanded genomic trinucleotide repeat regions in some neurological disorders. Crohn's disease, an inflammatory bowel disorder, has genetic influences, which remain undefined.

Effect of guar gum on mineral balances in NIDDM adults.

The self-selected diet of 16 subjects with non-insulin-dependent diabetes mellitus (NIDDM) was supplemented for 6 mo with either a granolalike bar containing 35.5 g carbohydrate and 6.6 g guar gum/bar or a placebo bar containing carbohydrate but no guar gum.

Diet and colorectal cancer.

Data on the relationship of dietary intakes to the risk of colorectal cancer is controversial. The identification of any single causal feature in human diet for colorectal cancer is an improbable outcome because of the complexity of neoplasia, interaction of dietary factors and carcinogens, and the varied forms of colorectal cancer. The same general dietary program advocated for reduced cardiovascular risk is probably suitable for cancer reduction as well.