Proteomic analysis of blood serum - a new approach to the search for diagnostic markers of bronchial asthma in children.

Currently, bronchial asthma (BA) is one of the most pressing medical and social problems, the molecular aspects of the formation and development of BA are insufficiently studied and the diagnosis is not perfect. Carrying out proteomic analysis of BA will not only reveal new biomarkers specific to this disease, but also bring us closer to understanding its pathogenetic mechanisms. The purpose of the study: to study the proteomic profile of blood serum of children with BA to identify proteins associated with this disease A comprehensive clinical and laboratory examination of children suffering from BA and control group patients was performed.

[OPTIMIZATION OF BRONCHODILATOR THERAPY FOR CHILDREN DURING ASTHMA EXACERBATION WITH ALLOWANCE FOR THE RISK OF DEVELOPMENT OF CARDIOHEMODYNAMIC DISORDERS].

We have studied the effect of bronchodilator drugs representing three groups--b2-adrenomimetic (fenoterol), anticholinergic (ipratropium bromide), and combined preparation (fenoterol/ipratropium bromide)--on cardiohemodynamics in children with acute asthma exacerbation. It is established that incorrect choice of bronchodilator most significantly influences the parameters of blood pressure and blood flow rate in the pulmonary artery, mitral and tricuspid valves, and also contributes to the appearance of signs of diastolic dysfunction of the right and left ventricles. A model predicting the risk of cardiohemodynamic violations was created using the multiple regression method, which allows the probability of negative changes in the cardiovascular system on the background of bronchodilator therapy to be calculated within several minutes using data on the medical prehistory and the results of objective and instrumental examination of a patient.

[Features of Autonomic Response in Children with Bronchial Asthma in the Period of Exacerbation].

Background: Asthma is one of the urgent problems of modern pediatrics, but neuroregulation mechanisms underlying this disease have not been fully disclosed so far. The autonomic interaction assessment in patients with bronchial asthma is important to understand the pathogenesis and prognosis of the disease.

Objective: The aim of this study was to investigate features of autonomic response in children with asthma in the period of exacerbation.

[Development of modified zirconia based dental material].

Ceramic materials are increasingly used in dentistry, because of their excellent biocompatibility. Zirconia based ceramic is unique among others due to its high flexural strength. This study examined physical and mechanical properties, as well as toxic and sanitary-chemical characteristics of zirconia based ceramics to select optimum compositions, in comply with the relevant requirements for medical consumables, particularly with materials for all-ceramic frameworks.