Gels
December 2024
In the original publication [...
View Article and Find Full Text PDFRecent studies of the spread of substances penetrating the disrupted blood-brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain's parenchyma when the blood-brain barrier is disrupted.
View Article and Find Full Text PDFGels
November 2024
For the first time, we introduced chemomechanical self-oscillating poly(N-isopropylacrylamide)-based gels containing catalytically active Fe or Ru complexes both as crosslinkers and as pendant groups. All the obtained gels exhibited sustained autonomous oscillations driven by the Belousov-Zhabotinsky reaction within their structure. The Ru complex-based gels also demonstrated pronounced chemomechanical oscillations; they periodically swelled/shrunk when the catalyst was reduced/oxidized.
View Article and Find Full Text PDFIntroduction: Primary age-related tauopathy (PART) is characterized by neurofibrillary tangles and minimal β-amyloid deposition, diagnosed postmortem. This study investigates F-flortaucipir (FTP) PET imaging for antemortem PART diagnosis.
Methods: We analyzed FTP PET scans from 50 autopsy-confirmed PART and 13 control subjects.