Publications by authors named "A I Lauerma"
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory came to light explaining the growing prevalence and exacerbations of these diseases worldwide.
View Article and Find Full Text PDFBackground: Psoriasis (Pso) is a chronic inflammatory skin disease that poses both physical and psychological challenges. Dysbiosis of the skin microbiome has been implicated in Pso, yet a comprehensive multi-omics analysis of host-microbe interactions is still lacking. To bridge this gap, we conducted an exploratory study by adopting the integrated approach that combines whole metagenomic shotgun sequencing with skin transcriptomics.
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- Angioedema (AE) is a condition characterized by localized swelling in the skin or mucous membranes and can be hereditary or acquired, making its classification complex due to various underlying mechanisms and taxonomies.
- The DANCE initiative, involving 91 experts from 35 countries, aimed to create a unified consensus on the definition, acronyms, and classification of AE through an extensive online discussion and voting process over 16 months.
- The resulting DANCE classification introduces five types of AE, standardizes terminology, and is designed to enhance research and patient care while complementing existing clinical guidelines without replacing them.
Article Synopsis
- The rapid advancement of precision diagnostic tools and omic technologies has led to the identification of new disease endotypes for allergic conditions, improving our understanding of diseases beyond just symptoms.
- This shift has prompted a reevaluation of current disease classifications, ultimately leading to the development of a modern nomenclature for allergic diseases that acknowledges historical classifications.
- The paper details a comprehensive framework for hypersensitivity reactions, categorizing them into nine types based on mechanisms and responses, with plans for a follow-up article addressing the practical implications in allergy treatment and management.